Predicting outcome in hematological stem cell transplantation.
نویسندگان
چکیده
This review summarizes recent results investigating the role of certain cytokine gene polymorphisms, including those of TNF-alpha, IFN-gamma, IL-6, IL-10 and IL-1 receptor antagonist (IL-1Ra), in allogeneic stem cell transplantation. It discusses their role in predicting outcome and the development of a genetic risk index for graft versus host disease (GvHD) in HLA-matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain cytokine gene polymorphisms may be associated with more severe disease.
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عنوان ژورنال:
- Archivum immunologiae et therapiae experimentalis
دوره 50 6 شماره
صفحات -
تاریخ انتشار 2002